31 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/01/2000 | H | EA All-Stars (Exhibition) | W | 95 | 87 | 13,926 | Louisville | Ky. | Freedom Hall | ||||||
| 11/17/2000 | A | Hawaii | W | 86 | 71 | 1-0 | 0-0 | 6,776 | Honolulu | Hawaii | Sheriff Center | ||||
| 11/20/2000 | N | 6 | Maryland | L | 73 | 95 | 1-1 | 0-0 | 2,500 | Lahaina | Hawaii | Lahaina Civic Center | 2000 Maui Invitational | ||
| 11/21/2000 | N | Nevada-Las Vegas | W | 86 | 85 | OT | 2-1 | 0-0 | 2,500 | Lahaina | Hawaii | Lahaina Civic Center | 2000 Maui Invitational | ||
| 11/22/2000 | N | 12 | Connecticut | L | 71 | 83 | 2-2 | 0-0 | 2,500 | Lahaina | Hawaii | Lahaina Civic Center | 2000 Maui Invitational | ||
| 11/30/2000 | A | Alabama | L | 71 | 100 | 2-3 | 0-0 | 13,375 | Tuscaloosa | Ala. | Coleman Coliseum | ||||
| 12/02/2000 | H | Global Sports (Exhibition) | L | 86 | 87 | 2OT | 8,746 | Louisville | Ky. | Freedom Hall | |||||
| 12/05/2000 | H | Georgetown | L | 63 | 70 | 2-4 | 0-0 | 18,586 | Louisville | Ky. | Freedom Hall | ||||
| 12/09/2000 | H | Western Kentucky | L | 65 | 68 | 2-5 | 0-0 | 18,427 | Louisville | Ky. | Freedom Hall | ||||
| 12/16/2000 | A | South Alabama | L | 65 | 72 | 2-6 | 0-0 | 9,019 | Mobile | Ala. | Mitchell Center | 2000 Coors Classic | |||
| 12/18/2000 | H | Loyola-Chicago | W | 86 | 70 | 3-6 | 0-0 | 10,206 | Louisville | Ky. | Freedom Hall | ||||
| 12/21/2000 | H | Murray State | W | 89 | 86 | 4-6 | 0-0 | 17,871 | Louisville | Ky. | Freedom Hall | ||||
| 12/23/2000 | H | Dayton | L | 68 | 91 | 4-7 | 0-0 | 18,739 | Louisville | Ky. | Freedom Hall | ||||
| 12/30/2000 | H | Oregon | L | 65 | 88 | 4-8 | 0-0 | 16,917 | Louisville | Ky. | Freedom Hall | ||||
| 01/02/2001 | H | Kentucky | L | 62 | 64 | 4-9 | 0-0 | 20,061 | Louisville | Ky. | Freedom Hall | ||||
| 01/06/2001 | A | Saint Louis | L | 61 | 71 | 4-10 | 0-1 | 12,237 | St. Louis | Mo. | Savvis Center | ||||
| 01/10/2001 | A | Tulane | W | 87 | 84 | OT | 5-10 | 1-1 | 3,069 | New Orleans | La. | New Orleans Arena | |||
| 01/13/2001 | H | Cincinnati | L | 52 | 72 | 5-11 | 1-2 | 19,892 | Louisville | Ky. | Freedom Hall | ||||
| 01/17/2001 | H | Houston | W | 79 | 67 | 6-11 | 2-2 | 17,214 | Louisville | Ky. | Freedom Hall | ||||
| 01/21/2001 | A | Southern Mississippi | L | 60 | 69 | 6-12 | 2-3 | 4,414 | Hattiesburg | Miss. | Reed Green Coliseum | ||||
| 01/24/2001 | A | Cincinnati | W | 63 | 54 | 7-12 | 3-3 | 13,176 | Cincinnati | Ohio | Shoemaker Center | ||||
| 01/27/2001 | H | DePaul | W | 73 | 63 | 8-12 | 4-3 | 17,437 | Louisville | Ky. | Freedom Hall | ||||
| 01/31/2001 | A | South Florida | L | 67 | 73 | 8-13 | 4-4 | 5,343 | Tampa | Fla. | USF Sun Dome | ||||
| 02/03/2001 | H | Saint Louis | L | 51 | 72 | 8-14 | 4-5 | 18,521 | Louisville | Ky. | Freedom Hall | ||||
| 02/08/2001 | H | Marquette | W | 75 | 65 | 9-14 | 5-5 | 15,390 | Louisville | Ky. | Freedom Hall | ||||
| 02/11/2001 | H | Charlotte | L | 72 | 106 | 9-15 | 5-6 | 15,156 | Louisville | Ky. | Freedom Hall | ||||
| 02/14/2001 | A | DePaul | W | 71 | 62 | 10-15 | 6-6 | 6,972 | Rosemont | Ill. | Allstate Arena | ||||
| 02/17/2001 | A | Utah | L | 67 | 84 | 10-16 | 6-6 | 12,171 | Salt Lake City | Utah | Huntsman Center | ||||
| 02/21/2001 | A | Charlotte | L | 68 | 74 | 10-17 | 6-7 | 6,325 | Charlotte | N.C. | Dale F. Halton Arena | ||||
| 02/24/2001 | A | Marquette | W | 77 | 74 | 3OT | 11-17 | 7-7 | 14,743 | Milwaukee | Wisc. | Bradley Center | |||
| 02/27/2001 | H | Alabama-Birmingham | L | 57 | 74 | 11-18 | 7-8 | 17,305 | Louisville | Ky. | Freedom Hall | ||||
| 03/03/2001 | H | Memphis | W | 65 | 56 | 12-18 | 8-8 | 19,920 | Louisville | Ky. | Freedom Hall | ||||
| 03/07/2001 | H | Alabama-Birmingham | L | 61 | 74 | 12-19 | 8-8 | 17,675 | Louisville | Ky. | Freedom Hall | 2001 C-USA Tournament First Round |