30 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/03/2003 | H | EA Sports (Exhibition) | W | 90 | 78 | 17,261 | Louisville | Ky. | Freedom Hall | ||||||
| 11/23/2003 | H | Asheville (NBDL) (Exhibition) | 17 | W | 73 | 59 | 15,831 | Louisville | Ky. | Freedom Hall | |||||
| 11/29/2003 | N | Iowa | 17 | L | 69 | 70 | OT | 0-1 | 0-0 | 19,213 | Indianapolis | Ind. | Conseco Fieldhouse | 2003 John Wooden Tradition | |
| 12/04/2003 | N | Western Kentucky | W | 93 | 63 | 1-1 | 0-0 | 12,120 | Nashville | Tenn. | Gaylord Entertainment Center | ||||
| 12/07/2003 | H | Holy Cross | W | 56 | 40 | 2-1 | 0-0 | 19,232 | Louisville | Ky. | Freedom Hall | ||||
| 12/10/2003 | H | Seton Hall | W | 80 | 71 | 3-1 | 0-0 | 19,328 | Louisville | Ky. | Freedom Hall | ||||
| 12/13/2003 | H | 1 | Florida | W | 73 | 65 | 4-1 | 0-0 | 20,032 | Louisville | Ky. | Freedom Hall | 2003 Billy Minardi Classic | ||
| 12/20/2003 | H | Austin Peay | 20 | W | 80 | 63 | 5-1 | 0-0 | 19,138 | Louisville | Ky. | Freedom Hall | |||
| 12/23/2003 | H | VMI | 20 | W | 107 | 56 | 6-1 | 0-0 | 18,174 | Louisville | Ky. | Freedom Hall | |||
| 12/27/2003 | A | 2 | Kentucky | 20 | W | 65 | 56 | 7-1 | 0-0 | 24,328 | Lexington | Ky. | Rupp Arena | ||
| 12/30/2003 | H | Toledo | 11 | W | 92 | 56 | 8-1 | 0-0 | 19,427 | Louisville | Ky. | Freedom Hall | |||
| 01/03/2004 | H | Murray State | 11 | W | 91 | 69 | 9-1 | 0-0 | 19,292 | Louisville | Ky. | Freedom Hall | |||
| 01/07/2004 | H | Southern Mississippi | 10 | W | 76 | 42 | 10-1 | 1-0 | 19,319 | Louisville | Ky. | Freedom Hall | |||
| 01/10/2004 | A | South Florida | 10 | W | 85 | 40 | 11-1 | 2-0 | 7,011 | Tampa | Fla. | USF Sun Dome | |||
| 01/15/2004 | A | East Carolina | 8 | W | 76 | 66 | 12-1 | 3-0 | 7,553 | Greenville | N.C. | Williams Arena at Minges Coliseum | |||
| 01/17/2004 | H | Tulane | 8 | W | 79 | 58 | 13-1 | 4-0 | 19,480 | Louisville | Ky. | Freedom Hall | |||
| 01/21/2004 | H | 6 | Cincinnati | 5 | W | 93 | 66 | 14-1 | 5-0 | 20,079 | Louisville | Ky. | Freedom Hall | ||
| 01/25/2004 | A | Tennessee | 5 | W | 65 | 62 | 15-1 | 5-0 | 15,086 | Knoxville | Tenn. | Thompson-Boling Arena | |||
| 01/28/2004 | H | Houston | 4 | W | 64 | 48 | 16-1 | 6-0 | 19,226 | Louisville | Ky. | Freedom Hall | |||
| 01/31/2004 | H | Marquette | 4 | L | 70 | 77 | 16-2 | 6-1 | 19,864 | Louisville | Ky. | Freedom Hall | |||
| 02/04/2004 | A | Memphis | 6 | L | 58 | 62 | 16-3 | 6-2 | 19,044 | Memphis | Tenn. | The Pyramid | |||
| 02/07/2004 | H | Alabama-Birmingham | 6 | W | 73 | 55 | 17-3 | 7-2 | 19,723 | Louisville | Ky. | Freedom Hall | |||
| 02/12/2004 | A | Charlotte | 9 | L | 71 | 77 | 17-4 | 7-3 | 9,105 | Charlotte | N.C. | Dale F. Halton Arena | |||
| 02/17/2004 | A | Texas Christian | 10 | L | 46 | 71 | 17-5 | 7-4 | 6,028 | Ft. Worth | Texas | Daniel-Meyer Coliseum | |||
| 02/21/2004 | A | 17 | Cincinnati | 10 | L | 61 | 66 | OT | 17-6 | 7-5 | 13,176 | Cincinnati | Ohio | Fifth Third Arena | |
| 02/25/2004 | H | DePaul | 21 | L | 58 | 60 | OT | 17-7 | 7-6 | 19,505 | Louisville | Ky. | Freedom Hall | ||
| 02/28/2004 | H | 19 | Memphis | 21 | W | 66 | 60 | 18-7 | 8-6 | 19,824 | Louisville | Ky. | Freedom Hall | ||
| 03/03/2004 | A | Saint Louis | 25 | W | 75 | 48 | 19-7 | 9-6 | 11,020 | St. Louis | Mo. | Savvis Center | |||
| 03/06/2004 | A | Marquette | 25 | L | 80 | 81 | 19-8 | 9-7 | 17,508 | Milwaukee | Wisc. | Bradley Center | |||
| 03/10/2004 | N | East Carolina | W | 61 | 54 | 20-8 | 9-7 | 13,877 | Cincinnati | Ohio | U.S. Bank Arena | 2004 C-USA Tournament First Round | |||
| 03/11/2004 | N | 13 | Cincinnati | L | 62 | 64 | 20-9 | 9-7 | 16,202 | Cincinnati | Ohio | U.S. Bank Arena | 2004 C-USA Tournament Quarterfinal | ||
| 03/19/2004 | N | Xavier | L | 70 | 80 | 20-10 | 9-7 | 15,961 | Orlando | Fla. | TD Waterhouse Centre | 2004 NCAA Tournament Atlanta Regional First Round |