31 games, 9 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/11/2015 | A | Puerto Rico Junior Team (Exhibition) | L | 88 | 94 | San Juan | P.R. | Jose Miguel Agrelot Coliseum | |||||||
| 08/11/2015 | A | Puerto Rico (Exhibition) | L | 81 | 89 | San Juan | P.R. | Jose Miguel Agrelot Coliseum | |||||||
| 08/12/2015 | A | Puerto Rico Junior Team (Exhibition) | L | 77 | 79 | San Juan | P.R. | Jose Miguel Agrelot Coliseum | |||||||
| 08/12/2015 | A | Puerto Rico (Exhibition) | L | 62 | 96 | San Juan | P.R. | Jose Miguel Agrelot Coliseum | |||||||
| 08/13/2015 | A | Puerto Rico (Exhibition) | L | 94 | 102 | Guaynabo | P.R. | Mario Morales Coliseum | |||||||
| 08/14/2015 | A | Puerto Rico (Exhibition) | W | 84 | 81 | Manati | P.R. | Municipal Coliseum | |||||||
| 08/15/2015 | A | Puerto Rico Junior Team (Exhibition) | W | 77 | 72 | Trujillo Alto | P.R. | Ruben Zayas Montanez Coliseum | |||||||
| 11/01/2015 | H | Bellarmine (Exhibition) | W | 71 | 55 | 18,612 | Louisville | Ky. | KFC Yum! Center | ||||||
| 11/09/2015 | H | Kentucky Wesleyan (Exhibition) | W | 77 | 68 | 15,794 | Louisville | Ky. | KFC Yum! Center | ||||||
| 11/13/2015 | H | Samford | W | 86 | 45 | 1-0 | 0-0 | 20,347 | Louisville | Ky. | KFC Yum! Center | ||||
| 11/17/2015 | H | Hartford | W | 87 | 52 | 2-0 | 0-0 | 18,910 | Louisville | Ky. | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | |||
| 11/21/2015 | H | North Florida | W | 89 | 61 | 3-0 | 0-0 | 20,413 | Louisville | Ky. | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | |||
| 11/24/2015 | H | St. Francis Brooklyn | W | 85 | 41 | 4-0 | 0-0 | 19,112 | Louisville | Ky. | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | |||
| 11/28/2015 | N | Saint Louis | W | 77 | 57 | 5-0 | 0-0 | 4,273 | Brooklyn | N.Y. | Barclays Center | 2015 Brooklyn Hoops Holiday Invitational | |||
| 12/02/2015 | A | 3 | Michigan State | 24 | L | 67 | 71 | 5-1 | 0-0 | 14,797 | East Lansing | Mich. | Breslin Center | 2015 Big Ten-ACC Challenge | |
| 12/05/2015 | H | Grand Canyon | 24 | W | 111 | 63 | 6-1 | 0-0 | 20,380 | Louisville | Ky. | KFC Yum! Center | |||
| 12/12/2015 | H | Eastern Michigan | 22 | W | 86 | 53 | 7-1 | 0-0 | 20,649 | Louisville | Ky. | KFC Yum! Center | |||
| 12/16/2015 | H | Kennesaw State | 19 | W | 94 | 57 | 8-1 | 0-0 | 19,288 | Louisville | Ky. | KFC Yum! Center | |||
| 12/19/2015 | H | Western Kentucky | 19 | W | 78 | 56 | 9-1 | 0-0 | 21,606 | Louisville | Ky. | KFC Yum! Center | |||
| 12/22/2015 | H | Missouri-Kansas City | 16 | W | 75 | 47 | 10-1 | 0-0 | 19,419 | Louisville | Ky. | KFC Yum! Center | 2015 Billy Minardi Classic | ||
| 12/23/2015 | H | Utah Valley | 16 | W | 98 | 68 | 11-1 | 0-0 | 19,146 | Louisville | Ky. | KFC Yum! Center | 2015 Billy Minardi Classic | ||
| 12/26/2015 | A | 12 | Kentucky | 16 | L | 73 | 75 | 11-2 | 0-0 | 24,412 | Lexington | Ky. | Rupp Arena | ||
| 01/03/2016 | H | Wake Forest | 18 | W | 65 | 57 | 12-2 | 1-0 | 21,302 | Louisville | Ky. | KFC Yum! Center | |||
| 01/07/2016 | A | North Carolina State | 16 | W | 77 | 72 | 13-2 | 2-0 | 17,762 | Raleigh | N.C. | PNC Arena | |||
| 01/10/2016 | A | Clemson | 16 | L | 62 | 66 | 13-3 | 2-1 | 9,562 | Greenville | S.C. | Bon Secours Wellness Arena | |||
| 01/14/2016 | H | 20 | Pittsburgh | 21 | W | 59 | 41 | 14-3 | 3-1 | 21,632 | Louisville | Ky. | KFC Yum! Center | ||
| 01/20/2016 | H | Florida State | 17 | W | 84 | 65 | 15-3 | 4-1 | 21,349 | Louisville | Ky. | KFC Yum! Center | |||
| 01/23/2016 | A | Georgia Tech | 17 | W | 75 | 71 | 16-3 | 5-1 | 7,829 | Atlanta | Ga. | McCamish Pavilion | |||
| 01/27/2016 | A | Virginia Tech | 16 | W | 91 | 83 | 17-3 | 6-1 | 7,084 | Blacksburg | Va. | Cassell Coliseum | |||
| 01/30/2016 | H | 11 | Virginia | 16 | L | 47 | 63 | 17-4 | 6-2 | 21,714 | Louisville | Ky. | KFC Yum! Center | ||
| 02/01/2016 | H | 2 | North Carolina | 19 | W | 71 | 65 | 18-4 | 7-2 | 22,781 | Louisville | Ky. | KFC Yum! Center | ||
| 02/06/2016 | H | Boston College | 19 | W | 79 | 47 | 19-4 | 8-2 | 21,803 | Louisville | Ky. | KFC Yum! Center | |||
| 02/08/2016 | A | Duke | 13 | L | 65 | 72 | 19-5 | 8-3 | 9,314 | Durham | N.C. | Cameron Indoor Stadium | |||
| 02/13/2016 | A | Notre Dame | 13 | L | 66 | 71 | 19-6 | 8-4 | 9,149 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 02/17/2016 | H | Syracuse | 18 | W | 72 | 58 | 20-6 | 9-4 | 21,654 | Louisville | Ky. | KFC Yum! Center | |||
| 02/20/2016 | H | 20 | Duke | 18 | W | 71 | 64 | 21-6 | 10-4 | 22,785 | Louisville | Ky. | KFC Yum! Center | ||
| 02/24/2016 | A | Pittsburgh | 11 | W | 67 | 60 | 22-6 | 11-4 | 10,425 | Pittsburgh | Pa. | Petersen Events Center | |||
| 02/27/2016 | A | 12 | Miami, Fla. | 11 | L | 65 | 73 | 22-7 | 11-5 | 7,342 | Coral Gables | Fla. | BankUnited Center | ||
| 03/01/2016 | H | Georgia Tech | 11 | W | 56 | 53 | 23-7 | 12-5 | 22,043 | Louisville | Ky. | KFC Yum! Center | |||
| 03/05/2016 | A | 4 | Virginia | 11 | L | 46 | 68 | 23-8 | 12-6 | 14,088 | Charlottesville | Va. | John Paul Jones Arena |