29 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12/01/1960 | H | Alabama | W | 90 | 53 | 1-0 | Louisville | Ky. | Freedom Hall | ||||||
| 12/03/1960 | H | Wittenberg | W | 56 | 36 | 2-0 | Louisville | Ky. | Freedom Hall | ||||||
| 12/06/1960 | A | Bellarmine | W | 79 | 52 | 3-0 | |||||||||
| 12/08/1960 | A | Kentucky Wesleyan | W | 74 | 73 | 4-0 | |||||||||
| 12/10/1960 | H | Xavier | W | 76 | 64 | 5-0 | Louisville | Ky. | Freedom Hall | ||||||
| 12/12/1960 | H | Georgia Tech | 9 | W | 74 | 65 | 6-0 | Louisville | Ky. | Freedom Hall | 1960 Bluegrass Invitational | ||||
| 12/13/1960 | H | Western Kentucky | 9 | W | 86 | 71 | 7-0 | Louisville | Ky. | Freedom Hall | 1960 Bluegrass Invitational | ||||
| 12/17/1960 | H | Georgetown College | 9 | W | 90 | 63 | 8-0 | Louisville | Ky. | Freedom Hall | |||||
| 12/21/1960 | H | Louisiana State | 5 | W | 72 | 53 | 9-0 | 2,218 | Louisville | Ky. | Freedom Hall | ||||
| 12/27/1960 | H | Brigham Young | 5 | W | 95 | 67 | 10-0 | 5,207 | Louisville | Ky. | Freedom Hall | ||||
| 12/31/1960 | A | 8 | Saint Louis | 5 | W | 49 | 47 | 11-0 | |||||||
| 01/04/1961 | H | Eastern Kentucky | 4 | W | 70 | 69 | 12-0 | Louisville | Ky. | Freedom Hall | |||||
| 01/07/1961 | A | Marquette | 4 | W | 84 | 63 | 13-0 | ||||||||
| 01/14/1961 | A | DePaul | 4 | L | 70 | 78 | 13-1 | Ill. | |||||||
| 01/18/1961 | A | Xavier | 5 | L | 77 | 84 | 13-2 | ||||||||
| 01/21/1961 | H | Dayton | 5 | W | 63 | 50 | 14-2 | Louisville | Ky. | Freedom Hall | |||||
| 01/25/1961 | H | Kentucky Wesleyan | 8 | W | 82 | 66 | 15-2 | Louisville | Ky. | Freedom Hall | |||||
| 01/30/1961 | A | Miami, Fla. | 8 | L | 69 | 71 | 15-3 | ||||||||
| 02/01/1961 | A | Tampa | 8 | W | 103 | 74 | 16-3 | ||||||||
| 02/03/1961 | A | Loyola, La. | 8 | W | 75 | 58 | 17-3 | ||||||||
| 02/08/1961 | A | Eastern Kentucky | 10 | L | 74 | 80 | 17-4 | ||||||||
| 02/15/1961 | H | Ohio | W | 117 | 84 | 18-4 | Louisville | Ky. | Freedom Hall | ||||||
| 02/18/1961 | A | Dayton | L | 71 | 91 | 18-5 | |||||||||
| 02/22/1961 | H | DePaul | L | 67 | 75 | 18-6 | Louisville | Ky. | Freedom Hall | ||||||
| 03/01/1961 | H | Western Kentucky | L | 80 | 96 | 18-7 | Louisville | Ky. | Freedom Hall | ||||||
| 03/06/1961 | H | Marquette | W | 75 | 50 | 19-7 | Louisville | Ky. | Freedom Hall | ||||||
| 03/14/1961 | H | Ohio | W | 76 | 70 | 20-7 | Louisville | Ky. | Freedom Hall | 1961 NCAA Tournament Mideast Regional First Round | |||||
| 03/17/1961 | H | 1 | Ohio State | L | 55 | 56 | 20-8 | Louisville | Ky. | Freedom Hall | 1961 NCAA Tournament Mideast Regional Seminfinal | ||||
| 03/18/1961 | H | Morehead State | W | 83 | 61 | 21-8 | Louisville | Ky. | Freedom Hall | 1961 NCAA Tournament Mideast Regional Third Place |